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Association between a functional polymorphism (‐1195T>C) in the IGFBP5 promoter and head and neck cancer risk
Author(s) -
Niu Jiangong,
Huang YuJing,
Wei Sheng,
Liu Zhensheng,
Wang LiE,
Chang Shine,
Chamberlain Robert M.,
ElNaggar Adel K.,
Sturgis Erich M.,
Wei Qingyi
Publication year - 2011
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21514
Subject(s) - head and neck cancer , head and neck , medicine , association (psychology) , oncology , polymorphism (computer science) , genetics , cancer , biology , genotype , psychology , gene , surgery , psychotherapist
Abstract Background. To the best of our knowledge, no studies to date have evaluated roles of insulin‐like growth factor binding protein 5 ( IGFBP5 ) polymorphisms in risk of squamous cell carcinoma of the head and neck (SCCHN).Methods. A hospital‐based study of 1082 patients with SCCHN and 1120 cancer‐free controls was performed to investigate associations between 2 functional polymorphisms, ‐1195T>C and ‐709G>C, in the IGFBP5 promoter region and SCCHN risk.Results. We demonstrated that the transcription factor, activator protein 1 (AP‐1), differentially bound to T or C variants at ‐1195 in the promoter to regulate the IGFBP5 promoter activity and that the C variant genotypes were associated with deferential risk of late‐stage SCCHN, compared to the TT genotype, particularly for human papillomavirus (HPV)‐unrelated sites (adjusted odds ratio [OR], 2.21; 95% confidence interval [CI], 1.19–4.11 for CC vs TT).Conclusion. The IGFBP5 ‐1195T>C polymorphism is functional and may potentially be a biomarker for susceptibility to late‐stage SCCHN. © 2010 Wiley Periodicals, Inc. Head Neck, 2011