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Positron emission tomography and positron emission tomography‐CT evaluation for recurrent papillary thyroid carcinoma: Meta‐analysis and literature review
Author(s) -
Miller Mia E.,
Chen Qiaolin,
Elashoff David,
Abemayor Elliot,
St. John Maie
Publication year - 2011
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21492
Subject(s) - positron emission tomography , thyroid carcinoma , medicine , thyroid cancer , nuclear medicine , carcinoma , radiology , meta analysis , thyroid , pet ct
Background Sensitivity and specificity data regarding positron emission tomography (PET) and PET/CT for surveillance of well‐differentiated thyroid cancer does not evaluate subtypes separately. Papillary and follicular thyroid carcinoma may have different characteristics on PET/CT imaging and so should be investigated individually. Methods This is a systematic meta‐analysis of studies using PET for surveillance in patients with papillary thyroid carcinoma. Results Using different statistical models, combined sensitivity of PET and PET/CT for papillary thyroid carcinoma was 77% by the fixed effect model and 82% by the random‐effects model, specificity was calculated as 85% and 84%, respectively. Meta‐regression was performed to evaluate whether I‐131 negativity affected PET positivity; no correlation between I‐131 negativity and PET sensitivity or specificity was found. Conclusion PET and PET/CT are useful modalities in surveillance of papillary thyroid carcinoma. To our knowledge, this is the first study to examine papillary thyroid carcinoma independently of other subtypes of well‐differentiated thyroid carcinoma. © 2010 Wiley Periodicals, Inc. Head Neck, 2011