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Mucoepidermoid carcinoma of the parotid gland: Factors affecting outcome
Author(s) -
GhoshLaskar Sarbani,
Murthy Vedang,
Wadasadawala Tabassum,
Agarwal Jaiprakash,
Budrukkar Ashwini,
Patil Nikhilesh,
Kane Shubhada,
Chaukar Devendra,
Pai Prathamesh,
Chaturvedi Pankaj,
D'Cruz Anil
Publication year - 2011
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21477
Subject(s) - mucoepidermoid carcinoma , medicine , parotid gland , radiation therapy , head and neck , lymph node , head and neck cancer , adjuvant radiotherapy , carcinoma , oncology , surgery , pathology
Background The purpose of this study was to identify the prognostic factors affecting the outcome in patients with mucoepidermoid carcinoma (MEC) of the parotid gland. Methods A total of 113 patients with MEC who were treated between 1993 and 2002 were analyzed. Results At median follow‐up of 49 months (range, 1–143 months), disease‐free survival (DFS) at 5 and 10 years was 84.6 and 84.6%, 80.7% and 67.3%, and 52.5% and 35.0% for low‐grade, intermediate‐grade, and high‐grade tumors, respectively. Five‐year and 10‐year overall survival was 96.8% for low‐grade tumors; 94.1% and 82.4%, respectively, for intermediate‐grade tumors; and 73.3% for high‐grade tumors. High‐grade tumors and lymph node cancer‐positive neck tumors strongly predicted poor locoregional control and DFS, while close or positive cut margins showed a trend toward poorer outcomes. Conclusion Histologic grade is the most important factor affecting outcome in parotid MEC. Adjuvant radiotherapy is recommended for high‐grade tumors and should be tailored according to the expected risk of recurrence for low‐grade and intermediate‐grade tumors. © 2010 Wiley Periodicals, Inc. Head Neck, 2011