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Calpain 10 gene and laryngeal cancer: A survival analysis
Author(s) -
MorenoLuna Ramón,
Abrante Antonio,
Esteban Francisco,
GonzálezMoles Miguel Angel,
DelgadoRodríguez Miguel,
Sáez María Eugenia,
GonzálezPérez Antonio,
RamírezLorca Reposo,
Real Luis Miguel,
Ruiz Agustín
Publication year - 2011
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21404
Subject(s) - genotype , hazard ratio , cancer , medicine , oncology , confidence interval , multivariate analysis , laryngeal neoplasm , biology , genetics , gene
Background Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. Calpains are Ca2+‐dependent cysteine proteases that modulate cellular function. A novel association between calpain 10 ( CAPN10 ) haplotypes and laryngeal cancer has been found recently. Therefore, the goal of this study was to analyze the contribution of CAPN10 alleles to laryngeal cancer survival. Methods Patients were recruited from southern Spain. Genotypes were determined using pyrosequencing technology. We analyzed CAPN10 UCSNP‐44, UCSNP‐43, UCSNP‐19, and UCSNP‐63 allelic distributions in 199 patients with unrelated laryngeal cancer. Survival curves were calculated from the date of the intervention to the date of death. Multivariate analyses were done using the Cox proportional risk model. Results UCSNP‐19, UCSNP‐43, and UCSNP‐44 were unrelated to survival in both univariate and multivariate analyses. However, for UCSNP‐63 genotype 12 a significant relationship was observed in multivariate analysis (hazard ratio [HR] = 2.73; 95% confidence interval [CI], 1.21–6.20). Conclusion CAPN10 UCSNP‐63 genotype 12 seems to be related with a worse prognosis in laryngeal cancer. © 2010 Wiley Periodicals, Inc. Head Neck, 2011