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Accuracy of whole‐body PET and PET‐CT in initial M staging of head and neck cancer: A meta‐analysis
Author(s) -
Xu GuoZeng,
Zhu XiaoDong,
Li MingYao
Publication year - 2011
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21400
Subject(s) - medicine , nuclear medicine , head and neck cancer , positron emission tomography , pet ct , head and neck , confidence interval , meta analysis , receiver operating characteristic , radiology , radiation therapy , surgery
Background A meta‐analysis was conducted to evaluate the accuracy of whole‐body positron emission tomography (PET) and PET‐CT in initial M staging of head and neck cancer. Methods After a systematic review of English language studies, sensitivity, specificity, and other measures of whole‐body PET and PET‐CT were pooled. Summary receiver operating characteristic (SROC) curves were also used to summarize overall test performance. Results Eight PET and 7 PET‐CT studies were identified. The pooled sensitivity estimates for PET and PET‐CT were 0.848 (95% confidence interval [CI], 0.776–0.905) and 0.875 (95% CI, 0.787–0.936). The pooled specificity estimates were 0.952 (95% CI, 0.933–0.967) and 0.950 (95% CI, 0.931–0.964). The Q* index estimates for PET‐CT (0.9409) were not significantly higher than for PET (0.9154; p > .05). Conclusion Whole‐body PET and PET‐CT have good diagnostic performance in initial M staging of head and neck cancer; although PET‐CT tends to have higher accuracy than PET. © 2010 Wiley Periodicals, Inc. Head Neck, 2011