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Utility of TL‐201 SPECT in clarifying false‐positive FDG‐PET findings due to osteoradionecrosis in head and neck cancer
Author(s) -
Wang ChihHsiu,
Liang JiAn,
Ding HueischJy,
Yang ShihNeng,
Yen KuoYang,
Sun ShungShung,
Kao ChiaHung
Publication year - 2010
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21377
Subject(s) - medicine , nuclear medicine , fluorodeoxyglucose , head and neck cancer , positron emission tomography , head and neck , osteoradionecrosis , lesion , cancer , radiology , standardized uptake value , radiation therapy , pathology , surgery
Background This study aimed to determine whether Tl‐201 single photon emission CT (SPECT) is potentially useful in differentiating false‐positive fluorodeoxyglucose positron emission tomography (FDG‐PET) findings caused by osteoradionecrosis (ORN) from recurrent head and neck cancer after radiotherapy. Methods Five patients were recruited. Dual‐phase FDG‐PET and dual‐phase Tl‐201 SPECT were performed for each patient. Results All 5 patients proved to have ORN without recurrent cancer. By visual interpretation, the results were 4 positive versus 1 negative for PET, and 4 negative versus 1 positive for Tl‐201 SPECT. The Tl‐201 SPECT clarified 3 of the 4 false‐positive PETs to be ORN. Dual‐phase semiquantitative studies showed decreased standardized uptake value (SUV) over time in 3 of the 4 false‐positive PETs and decreased lesion/background ratio over time in the false‐positive Tl‐201 SPECT. Conclusion The Tl‐201 SPECT may help clarify suspected false‐positive FDG uptake caused by ORN. Dual‐phase FDG‐PET and dual‐phase Tl‐201 SPECT may also have some value. © 2010 Wiley Periodicals, Inc. Head Neck, 2010