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Modern multimodality therapy for pediatric nonorbital parameningeal sarcomas
Author(s) -
Zevallos Jose P.,
Jain Kunal,
Roberts Dianna,
Santillan Alfredo A.,
Huh Winston,
Hanna Ehab Y.,
Kupferman Michael E.
Publication year - 2010
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21353
Subject(s) - medicine , rhabdomyosarcoma , radiation therapy , multimodal therapy , overall survival , head and neck , chemotherapy , surgery , radiology , sarcoma , pathology
Background Nonorbital parameningeal sarcomas are rare, aggressive tumors that arise predominantly in the pediatric population. The purpose of this study was to review their management and to clarify the role of surgery in their treatment. Methods Treatment, prognostic factors, and outcomes for patients over a 10‐year period were reviewed. Results In all, 34 patients were identified. The most common tumor site was the maxillary sinus, and 73% were rhabdomyosarcoma. Six patients (18%) presented with positive nodal metastases and 3 patients (10%) presented with distant metastases. Overall, 18 patients were treated surgically. Locoregional recurrence rate was 43%; no patients developed distant recurrence. Five‐year overall survival was 66.8%, disease‐specific survival was 68.1%, and disease‐free survival was 31.9%. Conclusions Pediatric nonorbital parameningeal sarcomas require aggressive multimodality treatment. Although chemotherapy and radiation constitute the treatment of choice in most cases, surgery may have a role as salvage therapy and in cases that fail to respond to chemoradiation. © 2010 Wiley Periodicals, Inc. Head Neck, 2010