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Better understanding tumor–host interaction in head and neck cancer to improve the design and development of immunotherapeutic strategies
Author(s) -
Badoual Cécile,
Sandoval Federico,
Pere Helene,
Hans Stephane,
Gey Alain,
Merillon Nathalie,
Van Ryswick Cordelia,
QuintinColonna Françoise,
Bruneval Patrick,
Brasnu Daniel,
Fridman Wolf H.,
Tartour Eric
Publication year - 2010
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21346
Subject(s) - immune system , head and neck , immunology , head and neck cancer , immunotherapy , cancer , medicine , biology , cancer research , surgery
Head and neck cancers are heavily infiltrated by immune cells, the significance of which is complex. The natural immune response against head and neck tumors, including anti‐human papillomavirus (HPV) T cells, and humoral responses has been clearly documented. However, during the course of tumor progression, co‐option of the immune system by tumor cells for their own advantage and increased resistance of tumor cells to immune attack also occur. Inflammation and immune subversion to support angiogenesis are key factors promoting tumor growth. Only a better understanding of this tumor–host interaction will permit a rational design of new immunotherapeutic approaches combining immunostimulation with drugs endowed with the ability to counteract immunoevasion mechanisms. © 2010 Wiley Periodicals, Inc. Head Neck, 2010