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Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas
Author(s) -
Hannisdal Kirsten,
BurumAuensen Espen,
Schjølberg Aasa,
De Angelis Paula M.,
Clausen Ole Petter F.
Publication year - 2010
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21342
Subject(s) - mad2 , immunohistochemistry , stage (stratigraphy) , tissue microarray , medicine , oncology , univariate analysis , pathology , multivariate analysis , cancer research , biology , cancer , cell cycle , cell cycle checkpoint , paleontology
Background. Spindle checkpoint proteins such as Mad2 and BubR1 are important for chromosome segregation during mitosis. The aim of the present study was to examine their possible impact on prognosis in tonsillar carcinomas and their relation to clinical variables, the prevalence of human papillomavirus (HPV), p53 status, and Ki‐67 positivity. Methods. We examined the expression of Mad2 and BubR1 by immunohistochemistry on tissue microarrays from 105 patients with tonsillar carcinomas. Results. BubR1 and Mad2 were both expressed in tonsillar carcinomas. Expression of BubR1 was a significant prognostic factor in univariate survival analysis. In multivariate analyses, BubR1 was a significant prognostic factor together with stage, age, and HPV status p < .01), whereas Mad2 did not show any significant correlations. Conclusion. We have shown that BubR1 expression is a novel and strong prognostic factor in tonsillar carcinomas, giving additional information to the TNM stage and other known prognostic factors. © 2010 Wiley Periodicals, Inc. Head Neck, 2010