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Glutathione S‐transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer
Author(s) -
Chen MuKuan,
Tsai HsiuTing,
Chung TsungTe,
Su ShihChi,
Kao TeYu,
Tseng HsienChun,
Liu TeHsiung,
Chiou HuiLing,
Yang ShunFa
Publication year - 2010
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21297
Subject(s) - gstp1 , allele , genotype , medicine , head and neck cancer , glutathione s transferase , cancer , confidence interval , oncology , gene , restriction fragment length polymorphism , gastroenterology , microbiology and biotechnology , biology , glutathione , genetics , enzyme , biochemistry
Background. The aim of this study was to estimate the relationship of glutathione S‐transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.Methods. Polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) was used to measure these 4 gene polymorphisms in 274 controls and 164 oral cancer patients.Results. Individuals with at least 1 varied G allele of GSTP1 had a 1.53‐fold risk (95% confidence interval [CI] = 1.01–2.31) of developing oral cancer compared with patients with wild‐type A/A homozygotes. Oral cancer patients with at least 1 varied T allele of GSTA1 gene had a 0.42‐fold risk (95% CI = 0.18–0.95) of having a tumor size >2 cm compared with patients with C/C homozygotes.Conclusions. The varied G allele of GSTP1 may be considered as a factor contributing to increased susceptibility, whereas the T allele of GSTA1 could be a protective factor for tumor size progression in Taiwanese with oral cancer. © 2009 Wiley Periodicals, Inc. Head Neck, 2010