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Transoral CO 2 laser treatment for T is –T 3 glottic cancer: The University of Brescia experience on 595 patients
Author(s) -
Peretti Giorgio,
Piazza Cesare,
Cocco Daniela,
De Benedetto Luigi,
Del Bon Francesca,
Redaelli De Zinis Luca Oscar,
Nicolai Piero
Publication year - 2010
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21278
Subject(s) - medicine , transoral laser microsurgery , univariate analysis , surgery , head and neck , retrospective cohort study , cancer , laser treatment , head and neck cancer , laser , multivariate analysis , radiation therapy , physics , optics
Background Transoral CO 2 laser surgery has been accepted as a valuable therapeutic option for glottic cancer. Methods This was a retrospective analysis of 595 patients. Five‐year overall and disease‐specific survivals, local control with laser, locoregional, regional control, and organ preservation rates were calculated. The impact of different variables was calculated by univariate analysis. Results Overall, disease‐specific and disease‐free survivals, local control with laser, locoregional, regional control, and organ preservation rates were 87.5%, 99%, 81.3%, 92.7%, 98.9%, 98.2%, and 97.1%, respectively. Univariate analysis showed a significant impact of pT category on local control with laser, organ preservation, locoregional and regional control, of endoscopic re‐treatment for positive deep surgical margins on local control with laser and organ preservation, and recurrence after endoscopic re‐treatment on local control with laser and organ preservation. Conclusion This series confirms the good oncologic outcomes of endoscopic laser surgery for T is , T 1 , and selected T 2 and T 3 glottic tumors. © 2009 Wiley Periodicals, Inc. Head Neck, 2010