Premium
Expression of matrix metalloproteinase‐1, ‐7, ‐9, ‐13, Ki‐67, and HER‐2 in epithelial‐myoepithelial salivary gland cancer
Author(s) -
Luukkaa Heikki,
Klemi Pekka,
Leivo Ilmo,
Mäkitie Antti A.,
Irish Jonathan,
Gilbert Ralph,
PerezOrdonez Bayardo,
Hirsimäki Pirkko,
Vahlberg Tero,
Kivisaari Atte,
Kähäri VeliMatti,
Grénman Reidar
Publication year - 2010
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21277
Subject(s) - myoepithelial cell , immunohistochemistry , matrix metalloproteinase , salivary gland , oncogene , salivary gland cancer , pathology , cancer , matrix metalloproteinase 9 , oncology , cancer research , chemistry , medicine , cell cycle
Background The expression of matrix metalloproteinases (MMPs) in epithelial‐myoepithelial salivary gland carcinoma has not been studied previously. Methods Immunohistochemistry for MMP‐1, ‐7, ‐9, ‐13, Ki‐67, and HER‐2, as well as HER‐2 gene amplification by silver enhanced in situ hybridization was performed in a series of 12 paraffin‐embedded histopathologic samples of patients from Canada and Finland. Results A positive MMP‐13 ( p = .0022), higher MMP‐13 ( p = .0274), and higher MMP‐9 ( p = .0274) index (multiplication of staining intensity by percentage of the positive cells) predicted better overall survival. In disease‐specific analysis, higher MMP‐9 index ( p = .0327) predicted better survival. A higher volume corrected index (VCI) of Ki‐67 ( p = .0339) predicted worse disease‐specific survival. In 1 patient, HER‐2 oncogene amplification was observed. Conclusion MMPs and Ki‐67 may have prognostic impact in epithelial‐myoepithelial carcinoma. © 2009 Wiley Periodicals, Inc. Head Neck, 2010