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Effect of repeated laser microsurgical operations on laryngeal cancer prognosis
Author(s) -
Karatzanis Alexander D.,
Waldfahrer Frank,
Psychogios Georgios,
Hornung Joachim,
Zenk Johannes,
Velegrakis George A.,
Iro Heinrich
Publication year - 2010
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21272
Subject(s) - transoral laser microsurgery , medicine , surgery , head and neck cancer , cancer , overall survival , head and neck , microsurgery , larynx , laryngeal neoplasm , surgical margin , radiation therapy , resection
Background The aim of this study was to evaluate whether repeated sessions of transoral CO 2 laser microsurgery (TLM) aiming to achieve clear histologic margins carry a negative effect on the prognosis of laryngeal cancer. Methods This was a retrospective evaluation of 763 cases that underwent primary TLM treatment for laryngeal cancer. Cases were compared for overall survival and local control rates with respect to status of surgical margins and number of procedures necessary to achieve these margins. Results No significant differences were noted among cases with negative surgical margins regardless of the number of procedures necessary to achieve these margins. On the other hand, positive margins at the end of surgical treatment carried significant negative prognostic effect. Conclusion The prognostic effect of negative surgical margins in TLM for laryngeal cancer is significant regardless of the number of procedures required to obtain such margins. © 2009 Wiley Periodicals, Inc. Head Neck, 2010