z-logo
Premium
Postoperative radiotherapy for primary early oral tongue cancer with pathologic N1 neck
Author(s) -
Chen TsengCheng,
Wang ChiTe,
Ko JenqYuh,
Lou PeiJen,
Yang TsungLin,
Ting LaiLei,
Wang ChunWei,
Hu YaLing,
Wang ChengPing
Publication year - 2010
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21217
Subject(s) - medicine , neck dissection , tongue , radiation therapy , port (circuit theory) , surgery , basal cell , head and neck cancer , adverse effect , overall survival , medical record , multivariate analysis , cancer , glossectomy , pathology , electrical engineering , engineering
Background The benefit of postoperative radiotherapy (PORT) for early squamous cell carcinoma of the tongue (SCCOT) with pathologic N1 disease remains unclear. Methods The medical records of all patients with pathologic T1‐2/N0‐1 SCCOT who underwent wide excision of the primary tumor and neck dissection between 1980 and 2002 were reviewed. Results There were 59 patients analyzed, including 28 patients with and 31 patients without PORT. The 5‐year disease‐free survival rates were 81.2% and 53% for the patients with and without PORT, respectively ( p = .03). The overall 5‐year survival rates were 77% and 70.5% for the patients with and without PORT, respectively ( p = .36). Multivariate analyses showed that PORT had the only protective effect ( p = .01) and extracapsular spread (ECS) was the only significantly adverse factor for locoregional recurrence ( p = .03). Conclusions Approximately one‐third of the patients who received only surgery had locoregional recurrence. PORT significantly improved the disease‐free survival. © 2009 Wiley Periodicals, Inc. Head Neck, 2010

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here