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Importance of comorbidity in hypopharyngeal cancer
Author(s) -
Homma Akihiro,
Sakashita Tomohiro,
Oridate Nobuhiko,
Suzuki Fumiyuki,
Suzuki Seigo,
Hatakeyama Hiromitsu,
Mizumachi Takatsugu,
Taki Shigenari,
Fukuda Satoshi
Publication year - 2010
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21158
Subject(s) - comorbidity , medicine , proportional hazards model , multivariate analysis , head and neck cancer , stage (stratigraphy) , cancer , hypopharyngeal cancer , retrospective cohort study , survival analysis , head and neck , surgery , paleontology , biology
Background. Comorbidity has an impact on survival in laryngeal cancer in several reports. However, the importance of comorbidity in hypopharyngeal cancer (HPC) has not been reported. Methods. A retrospective medical record review of 156 patients with HPC treated between 1995 and 2005 was performed. Comorbid illness was measured by the Adult Comorbidity Evaluation‐27. A Cox proportional hazards model was used to determine the factors related to overall survival. Results. Comorbidity was absent in 55 (35.2%) of the patients, mild in 39 (25%), moderate in 28 (17.9%), and severe in 34 (21.8%). There were statistically significant differences between the survival rates in accord with age, stage, subsite, and comorbidity (45.1% for none or mild vs 27.7% for moderate or severe; p = .0073). Age, stage, and comorbidity were identified as independent prognostic factors in the multivariate analysis. Conclusion. Comorbidity, along with the clinical stage, should be considered in treatment planning for patients with HPC. © 2009 Wiley Periodicals, Inc. Head Neck, 2010