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Predictors of outcome for advanced‐stage supraglottic laryngeal cancer
Author(s) -
Ganly Ian,
Patel Snehal G.,
Matsuo Jeanette,
Singh Bhuvanesh,
Kraus Dennis H.,
Boyle Jay,
Wong Richard J.,
Lee Nancy,
Pfister David G.,
Shaha Ashok R.,
Shah Jatin P.
Publication year - 2009
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21113
Subject(s) - medicine , stage (stratigraphy) , radiation therapy , chemoradiotherapy , t stage , multivariate analysis , neck dissection , head and neck cancer , carcinoma , surgery , cancer , overall survival , paleontology , biology
Background. The objective of this study was to report our experience in the management of patients with advanced‐stage supraglottic laryngeal carcinoma and to identify factors predictive of outcome.Methods. In total, 181 patients with advanced‐stage supraglottic laryngeal carcinoma were treated at Memorial Sloan‐Kettering Cancer Center between 1984 and 1998. Sixty‐nine (38%) patients were treated by surgery ± postoperative radiotherapy (SRT), 93 (52%) by chemoradiotherapy (CTRT), and 19 (10%) by radiotherapy alone (RT). Survival outcomes were calculated using the Kaplan‐Meier method. Predictors of outcome were identified using multivariate analysis.Results. The‐5 year overall survival (OS) and disease‐specific survival (DSS) were 53% and 71%, respectively. Patients treated with SRT and CTRT had comparable outcomes. The main independent predictors of OS and DSS were age greater than 60 years and stage of the neck at presentation.Conclusion. Regardless of index treatment, age over 60 years and clinical stage of the neck at presentation were the main independent predictors of OS and DSS. © 2009 Wiley Periodicals, Inc. Head Neck, 2009