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Contribution of genetic polymorphisms of stromal cell–derived factor‐1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer
Author(s) -
Teng YingHock,
Liu TeHsiung,
Tseng HsienChun,
Chung TsungTe,
Yeh ChiaMing,
Li YuChiung,
Ou YuHsiang,
Lin LongYau,
Tsai HsiuTing,
Yang ShunFa
Publication year - 2009
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21094
Subject(s) - allele , cancer , biology , heterozygote advantage , cxcr4 , stromal cell derived factor 1 , cancer research , metastasis , oncology , medicine , gene , genetics , receptor , chemokine
Background. The aim of this study was to evaluate the relations of SDF‐1 and its receptor, CXCR4, gene variants on oral cancer risk.Methods. PCR‐RFLP was used to measure SDF‐1 ‐3′A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer.Results. After being adjusted for age, individuals with A/G heterozygotes of SDF‐1 had a higher risk of 1.86‐fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66‐fold to progress to stage III or IV.Conclusions. SDF‐1 ‐3′A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph‐node metastasis of oral cancer disease in Taiwanese. © 2009 Wiley Periodicals, Inc. Head Neck, 2009