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Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer
Author(s) -
Demircan Kadir,
Gunduz Esra,
Gunduz Mehmet,
Beder Levent Bekir,
Hirohata Satoshi,
Nagatsuka Hitoshi,
Cengiz Beyhan,
Cilek Mehmet Zeynel,
Yamanaka Noboru,
Shimizu Kenji,
Ninomiya Yoshifumi
Publication year - 2009
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21045
Subject(s) - adamts , matrix metalloproteinase , metastasis , thrombospondin , disintegrin , metalloproteinase , cancer research , cancer , population , medicine , primary tumor , tumor progression , head and neck cancer , pathology , biology , oncology , environmental health
Abstract Background. Although contribution of matrix metalloproteinases in cancer progression and dissemination is now well known, roles of recently discovered metalloproteinases, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), in cancer development and progression remain mostly unknown. Methods. Here we examined the mRNA expression pattern of 6 members of ADAMTS aggrecanases (1, 4, 5, 8, 9, and 15) in primary head and neck cancer with and without metastasis by real‐time reverse transcriptase‐polymerase chain reaction. Results. Expression levels of ADAMTS mRNAs were lower in the majority of the primary tumors as compared with the controls. On the other hand, the expression levels of all of the ADAMTS mRNAs except ADAMTS4 were higher in the metastatic foci than in their corresponding primary tumors, which suggest that characteristics of the cancer cell population are different in the primary tumor and metastatic focus. Conclusion. Our findings suggest a metastasis model proposing accumulation of a subtype of cancer cells with high metastatic capacity within heterogenous primary tumor cell population.© 2009 Wiley Periodicals, Inc. Head Neck, 2009