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Higher laryngeal preservation rate after CO 2 laser surgery compared with radiotherapy in T1a glottic laryngeal carcinoma
Author(s) -
Schrijvers Michiel L.,
van Riel Eva L.,
Langendijk Johannes A.,
Dikkers Frederik G.,
Schuuring Ed,
van der Wal Jacqueline E.,
A. M. van der Laan Bernard F.
Publication year - 2009
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21027
Subject(s) - medicine , radiation therapy , laser surgery , surgery , carcinoma , larynx , laryngeal neoplasm , stage (stratigraphy) , laser , paleontology , physics , optics , biology
Abstract Background. Clinical outcome of endoscopic CO 2 laser surgery and radiotherapy in early‐stage glottic laryngeal carcinoma is difficult to compare because of differences in treatment selection and patient groups. Therefore, we compared local control, overall survival, and laryngeal preservation in a homogenous group of patients with T1a glottic carcinoma with normal/diminished mucosal wave treated with either CO 2 laser surgery or radiotherapy. Methods. Retrospective survival analysis was performed on 100 patients with T1a glottic carcinoma treated with CO 2 laser surgery ( n = 49) or radiotherapy ( n = 51), diagnosed at the University Medical Center Groningen between 1990 and 2004. Results. No significant differences in local control and overall survival were found. Ultimate 5‐year laryngeal preservation was significantly better in the CO 2 laser surgery group (95% vs 77%, p = .043). Conclusion. Patients with T1a glottic carcinoma with normal/diminished mucosal wave treated with CO 2 laser surgery had a significantly better laryngeal preservation rate than patients treated with radiotherapy. © 2009 Wiley Periodicals, Inc. Head Neck, 2009