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Association between Helicobacter pylori infection and laryngohypopharyngeal carcinoma: A case–control study and review of the literature
Author(s) -
Rezaii Jalal,
Tavakoli Hassan,
Esfandiari Khalil,
Ashegh Hossein,
Hasibi Mehrdad,
Ghanei Gholamreza,
KhoshBatn Mahnaz,
Rashidi Armin
Publication year - 2008
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20918
Subject(s) - helicobacter pylori , medicine , odds ratio , gastroenterology , risk factor , carcinoma , case control study , pharynx , serology , cancer , immunology , surgery , antibody
Background. Gastroesophageal reflux, by exposing the pharynx to Helicobacter pylori ( H. pylori ), is a potential risk factor for laryngohypopharyngeal carcinoma. Its possible association has been inconsistent. In this case–control study, we investigated the relationship between H. pylori seropositivity and laryngohypopharyngeal carcinoma in Iran. Methods. We had 105 healthy controls (group A), 70 cases of laryngeal carcinoma (group B), and 28 cases of hypopharyngeal carcinoma group (group C). Age, sex, smoking habit, alcohol use, and H. pylori serology were determined for all subjects. Results. Groups were matched in age and alcohol use. Smoking and H. pylori seropositivity were more common in groups B and C, and male sex was more common in group B (compared with group A). In multivariate regression, the effect of smoking ( p <.01, odds ratio [OR] = 2.92) and H. pylori seropositivity ( p <.01, OR = 11.49) remained highly significant. Conclusion. H. pylori is an independent risk factor for laryngohypopharyngeal carcinoma. © 2008 Wiley Periodicals, Inc. Head Neck, 2008