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Accuracy of 18F‐FDG‐PET/CT for staging of oral squamous cell carcinoma
Author(s) -
Pentenero Monica,
Cistaro Angela,
Brusa Mario,
Ferraris Maria Maddalena,
Pezzuto Carla,
Carnino Riccardo,
Colombini Edro,
Valentini Maria Consuelo,
Giovanella Luca,
Spriano Giuseppe,
Gandolfo Sergio
Publication year - 2008
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20906
Subject(s) - medicine , radiology , positron emission tomography , nuclear medicine , head and neck squamous cell carcinoma , basal cell , primary tumor , head and neck , pet ct , predictive value , false positive paradox , diagnostic accuracy , head and neck cancer , cancer , radiation therapy , metastasis , pathology , surgery , machine learning , computer science
Background. This study prospectively assessed 2‐[F18]‐fluoro‐2‐deoxy‐ D ‐glucose–positron emission tomography (18F‐FDG‐PET)/CT (PET/CT) in oral squamous cell carcinoma. Methods. Twenty‐three patients completed preoperative TNM staging (CT, MR, whole‐body fusion imaging PET/CT). In patients who underwent surgical therapy (19 of 23), TNM staging based on PET/CT scan was compared with pTNM. Results. PET/CT correctly staged 16 of 19 primary tumors (accuracy 84.2%, sensitivity 84.2%, positive predictive value 100%) and correctly ruled out bone invasion in 3 patients with false‐positive results according to CT and/or MR. PET/CT incorrectly identified neck involvement in 5 of 15 patients (3 false positives, 2 false negatives) who underwent neck dissection (accuracy 66.7%, specificity 76.9%, negative predictive value 83.3%). False‐negative cases showed a nodal size not exceeding 10 mm. One patient with a bronchial synchronous primary tumor was identified. Conclusion. PET/CT scan showed good accuracy in determining the extension and/or depth of invasion of the primary tumor. Nevertheless, PET/CT was not accurate to rule out nodal metastases. © 2008 Wiley Periodicals, Inc. Head Neck, 2008