Accuracy of 18F‐FDG‐PET/CT for staging of oral squamous cell carcinoma | Zendy

Pentenero Monica | Zendy; Cistaro Angela | Zendy; Brusa Mario | Zendy; Ferraris Maria Maddalena | Zendy; Pezzuto Carla | Zendy; Carnino Riccardo | Zendy; Colombini Edro | Zendy; Valentini Maria Consuelo | Zendy; Giovanella Luca | Zendy; Spriano Giuseppe | Zendy; Gandolfo Sergio | Zendy

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Accuracy of 18F‐FDG‐PET/CT for staging of oral squamous cell carcinoma

Author(s) -

Pentenero Monica,

Cistaro Angela,

Brusa Mario,

Ferraris Maria Maddalena,

Pezzuto Carla,

Carnino Riccardo,

Colombini Edro,

Valentini Maria Consuelo,

Giovanella Luca,

Spriano Giuseppe,

Gandolfo Sergio

Publication year - 2008

Publication title -

head and neck

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 127

eISSN - 1097-0347

pISSN - 1043-3074

DOI - 10.1002/hed.20906

Subject(s) - medicine , radiology , positron emission tomography , nuclear medicine , head and neck squamous cell carcinoma , basal cell , primary tumor , head and neck , pet ct , predictive value , false positive paradox , diagnostic accuracy , head and neck cancer , cancer , radiation therapy , metastasis , pathology , surgery , machine learning , computer science

Background. This study prospectively assessed 2‐[F18]‐fluoro‐2‐deoxy‐ D ‐glucose–positron emission tomography (18F‐FDG‐PET)/CT (PET/CT) in oral squamous cell carcinoma. Methods. Twenty‐three patients completed preoperative TNM staging (CT, MR, whole‐body fusion imaging PET/CT). In patients who underwent surgical therapy (19 of 23), TNM staging based on PET/CT scan was compared with pTNM. Results. PET/CT correctly staged 16 of 19 primary tumors (accuracy 84.2%, sensitivity 84.2%, positive predictive value 100%) and correctly ruled out bone invasion in 3 patients with false‐positive results according to CT and/or MR. PET/CT incorrectly identified neck involvement in 5 of 15 patients (3 false positives, 2 false negatives) who underwent neck dissection (accuracy 66.7%, specificity 76.9%, negative predictive value 83.3%). False‐negative cases showed a nodal size not exceeding 10 mm. One patient with a bronchial synchronous primary tumor was identified. Conclusion. PET/CT scan showed good accuracy in determining the extension and/or depth of invasion of the primary tumor. Nevertheless, PET/CT was not accurate to rule out nodal metastases. © 2008 Wiley Periodicals, Inc. Head Neck, 2008

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