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MMPs, TIMP‐2, and TGF‐β1 in the cancerization of oral lichen planus
Author(s) -
Chen Yu,
Zhang Weiping,
Geng Ning,
Tian Kun,
Jack Windsor Lester
Publication year - 2008
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20869
Subject(s) - oral lichen planus , matrix metalloproteinase , pathology , medicine , immunohistochemistry , malignant transformation , pathological
Background. Matrix metalloproteinases (MMPs) and transforming growth factor‐β1 (TGF‐β1) are important in many physiological and pathological processes. Methods. Immunohistochemistry for MMP‐2, MMP‐9, membrane‐type 1 MMP (MT1‐MMP, MMP‐14), tissue inhibitor of matrix metalloproteinase (TIMP)‐2, and TGF‐β were performed on normal mucosa, nonatrophic oral lichen planus, atrophic oral lichen planus, and oral squamous cell carcinomas (OSCC) resulting from lichen planus. Results. Expression of MMPs progressively increased from normal mucosa to nonatrophic oral lichen planus, atrophic oral lichen planus, and OSCCs. Immunoscores of MMPs in atrophic oral lichen planus was significantly greater than nonatrophic oral lichen planus. Moreover, immunoscore of MMP‐9 of OSCCs was significantly greater than both atrophic and nonatrophic lichen planus. Furthermore, expression of TIMP‐2 and TGF‐β1 paralleled increases seen with MMPs. Conclusions. Imbalance between MMPs and TIMPs may be involved in cancerization of oral lichen planus. MMP‐2, MT1‐MMP, and especially MMP‐9 may be useful markers for judging potency of malignant transformation from oral lichen planus. © 2008 Wiley Periodicals, Inc. Head Neck 2008