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Definitive radiation therapy for squamous cell carcinoma of the soft palate
Author(s) -
Chera Bhishamjit S.,
Amdur Robert J.,
Hinerman Russell W.,
Morris Christopher G.,
Villaret Douglas B.,
Werning John W.,
Mendenhall William M.
Publication year - 2008
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20848
Subject(s) - medicine , radiation therapy , stage (stratigraphy) , neck dissection , soft palate , surgery , basal cell , head and neck , survival rate , carcinoma , paleontology , biology
Background. We report the University of Florida experience with soft‐palate carcinoma treated with radiotherapy alone or combined with adjuvant chemotherapy and/or neck dissection for residual disease in the neck. Methods. A total of 145 patients treated with curative intent from 1963 to 2004 were included. Potential follow‐up was ≥2 years. Results. Local control rates at 5 years were: T1, 90%; T2, 91%; T3, 67%; T4, 57%. Nodal control rates at 5 years were: N0, 90%; N1, 82%; N2, 68%; N3, 71%. Ultimate local‐regional control rates at 5 years were: stage I, 89%; stage II, 88%; stage III, 96%; stage IVA, 63%; stage IVB, 43%. In multivariate analysis, overall treatment time significantly affected local and ultimate local‐regional control, and nodal stage significantly affected overall survival. Overall survival rate at 5 years was 44%. Cause‐specific survival rate at 5 years was 73%. Conclusions. The likelihood of cure after definitive radiotherapy is relatively high and is impacted by disease extent and overall treatment time. © 2008 Wiley Periodicals, Inc. Head Neck 2008