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Clinical significance of osteopontin expression in T1 and T2 tongue cancers
Author(s) -
Chien ChihYen,
Su ChihYing,
Chuang HuiChing,
Fang FuMin,
Huang HsuanYing,
Chen ChingMei,
Chen ChangHan,
Huang ChaoCheng
Publication year - 2008
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20783
Subject(s) - osteopontin , immunohistochemistry , endoglin , angiogenesis , medicine , tumor necrosis factor alpha , tongue , pathology , metastasis , clinical significance , oncology , cancer research , cancer , biology , stem cell , cd34 , genetics
Background Osteopontin (OPN) is considered to be a tumor‐related protein associated with tumor aggressiveness and metastasis. Methods Immunohistochemistry was used to study the clinical significance of OPN expression in T1 and T2 tongue cancers. Results Positive OPN expression significantly correlated with higher tumor classification (T) ( p = .004), positive nodal classification (N) ( p < .001), greater tumor thickness ( p < .001), and presence of tumor necrosis ( p = .016), respectively. The unfavorable cumulative 5‐year disease‐free survival rate significantly correlated with positive OPN expression ( p < .001), T2 ( p = .024), positive N ( p < .001), greater tumor thickness ( p = .023), and positive tumor necrosis ( p = .003). However, taking CD105 into consideration, only CD105 expression was the independent prognostic factor for survival by Cox's regression analysis. Conclusion Overexpression of OPN in the tumors implicated a more aggressive tumor behavior and was an important factor for survival. In addition, there might be relationship between OPN and CD105 expressions in angiogenesis. © 2008 Wiley Periodicals, Inc. Head Neck, 2008