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Adult T‐cell leukemia/lymphoma with multiple integration of HTLV‐1 provirus presenting as an isolated paranasal sinus tumor: A case report
Author(s) -
Nagasaki Akitoshi,
Miyagi Takashi,
Taira Tamiko,
Shinhama Akihiko,
Kojya Shizuo,
Suzuki Mikio,
Aonahata Miyuki,
Yoshimi Naoki,
Takasu Nobuyuki
Publication year - 2008
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20730
Subject(s) - provirus , medicine , lymphoma , adult t cell leukemia/lymphoma , leukemia , t cell leukemia , sinus (botany) , pathology , virology , cancer research , immunology , biology , gene , botany , genus , genome , biochemistry
Background. Adult T‐cell leukemia/lymphoma (ATLL) is a highly aggressive T‐cell lymphoma and etiologically associated with human T‐lymphotropic virus type 1 (HTLV‐1). Patients with ATLL commonly present with leukemic changes, systemic lymphadenopathy, and/or extranodal lesion and have very poor prognosis. Methods and Results. We describe a rare case of ATLL presenting as an isolated paranasal mass. Southern blot analysis of the biopsied specimens demonstrated multiple integration bands of HTLV‐1 provirus of different intensities. Chemotherapy resulted in complete resolution of the paranasal mass. Thereafter, the patient showed an indolent clinical course with leukemic changes and pulmonary and cutaneous ATLL lesions and remains alive more than 5 years from diagnosis. Conclusion. ATLL should be included in the differential diagnosis of sinonasal lymphoma, although the event is rare. Multiple HTLV‐1 provirus integrations of different intensities may be indicative of good prognosis for ATLL. © 2007 Wiley Periodicals, Inc. Head Neck, 2008