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Successful treatment of pulmonary metastatic salivary ductal carcinoma with trastuzumab‐based therapy
Author(s) -
Prat Aleix,
Parera Marta,
Reyes Vicky,
Peralta Sergio,
Cedrés Susana,
Andreu Jordi,
Huguet Pere,
del Campo Josep Maria
Publication year - 2008
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20714
Subject(s) - medicine , trastuzumab , radiation therapy , oncology , systemic therapy , lymph node , chemotherapy , salivary gland , radiology , cancer , breast cancer
Background Salivary ductal carcinoma (SDC) is an uncommon malignant tumor of the salivary glands. Although there is no known standard of care for the treatment of advanced disease, the vast majority of patients with SDC may be offered palliative systemic therapy. We report a case of epidermal growth factor receptor 2 (HER2)‐positive metastatic submandibular SDC with a complete and durable clinical response to treatment with trastuzumab in combination with chemotherapy. Methods and Results A 62‐year‐old man was diagnosed with SDC of the left submandibular gland with extensive cervical lymph node involvement. The lesion was completely resected, and the patient underwent postoperative radiotherapy. After 6 months, multiple pulmonary metastatic lesions were detected. A complete response was reached with trastuzumab‐based combination therapy, and no evidence of disease progression has been observed after 14 months of initiation of systemic therapy. Conclusion Trastuzumab‐based combination therapies should be considered for advanced SDC. © 2007 Wiley Periodicals, Inc. Head Neck 2008