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Polymorphism of C‐terminal activation region 2 of Epstein‐Barr virus latent membrane protein 1 in predicting distant failure and post‐metastatic survival in patients with nasopharyngeal carcinoma
Author(s) -
Pai PingChing,
Tseng ChenKan,
Chuang ChiCheng,
Wei KuoChen,
Hao ShengPo,
Hsueh Chuen,
Chang KaiPing,
Tsang NganMing
Publication year - 2007
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20483
Subject(s) - nasopharyngeal carcinoma , metastasis , distant metastasis , epstein–barr virus , virus , polymerase chain reaction , oncology , carcinoma , medicine , survival analysis , cancer research , biology , pathology , gene , virology , cancer , genetics , radiation therapy
Background. The C‐terminal activation region 2 (CTAR2) of Epstein‐Barr virus latent membrane protein 1 is the major site that correlates with metastasis‐related signaling pathway. The variation of CTAR2 sequence may affect the incidence of distant metastasis in patients with nasopharyngeal carcinoma (NPC). Methods. Two hundred forty‐nine specimens from consecutive patients with nonmetastatic NPC were collected. Amplification by polymerase chain reaction and sequence analysis of CTAR2 were performed. DNA sequence identical to the Cao strain was grouped as Cao CTAR2, whereas sequences differing from Cao made up non‐Cao CTAR2. Clinical characteristics and CTAR2 status were subjected to statistical analysis for distant metastasis. Results. Non‐Cao CTAR2 was associated with a statistically significant lower distance metastasis and superior survival rate. A combination of clinical stage and CTAR2 expression provided an accurate method of identifying high risk of metastasis. Conclusion. NPC patients with non‐Cao CTAR2 were less likely to have metastasis develop than those characterized by Cao CTAR2. © 2006 Wiley Periodicals, Inc. Head Neck 2007