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Head and neck squamous cell carcinoma cell lines: Established models and rationale for selection
Author(s) -
Lin Charles J.,
Grandis Jennifer R.,
Carey Thomas E.,
Gollin Susanne M.,
Whiteside Theresa L.,
Koch Wayne M.,
Ferris Robert L.,
Lai Stephen Y.
Publication year - 2007
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20478
Subject(s) - head and neck squamous cell carcinoma , cell culture , compendium , cell , cancer research , cancer , head and neck cancer , oncology , medicine , biology , genetics , history , archaeology
Background. Head and neck squamous cell carcinoma (HNSCC) cell lines are important preclinical models in the search for novel and targeted therapies to treat head and neck cancer. Unlike many other cancer types, a wide variety of primary and metastatic HNSCC cell lines are available. An easily accessible guide that organizes important characteristics of HNSCC cell lines would be valuable for the selection of appropriate HNSCC cell lines for in vitro or in vivo studies. Methods. A literature search was performed. Results. Cell growth and culture parameters from HNSCC cell lines were catalogued into tables or lists of selected characteristics. Methods for establishing cancer cell lines and basic cell culture maintenance techniques were reviewed. Conclusions. A compendium of HNSCC cell line characteristics is useful for organizing the accumulating information regarding cell line characteristics to assist investigators with the development of appropriate preclinical models. © 2006 Wiley Periodicals, Inc. Head Neck, 2006