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Association of the A870G cyclin D1 gene polymorphism with genetic susceptibility to nasopharyngeal carcinoma
Author(s) -
Catarino Raquel J.,
Breda Eduardo,
Coelho Vânia,
Pinto Daniela,
Sousa Hugo,
Lopes Carlos,
Medeiros Rui
Publication year - 2006
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20377
Subject(s) - nasopharyngeal carcinoma , genetics , gene , cyclin d1 , biology , polymorphism (computer science) , genetic predisposition , genotype , medicine , cell cycle , radiation therapy
Background. Nasopharyngeal cancer (NPC) is multifactorial, and the genetic background may be a crucial etiologic factor. Cyclin D1 (CCND1) is a key regulator of the cell cycle, and its altered activity is associated with the development of cancer. Methods. We analyzed the A870G CCND1 polymorphism by polymerase chain reaction/restriction fragment length polymorphism (PCR‐RFLP) in 281 individuals, including 94 patients with NPC and 187 healthy individuals. Results. Our results indicate that individuals carrying two G alleles have a 2.17‐fold increase in the risk for the development of NPC (odds ratio [OR], 2.17; 95% confidence interval [CI], 1.19–3.98; p = .016). Age‐adjusted logistic regression analysis confirmed this association (adjusted odds ratio [aOR], 2.14; 95% CI, 1.14–4.04; p = .018). Multivariate analysis demonstrates an independent association between GG CCND1 genotype (aOR, 2.06), male sex (aOR, 2.66), and age at diagnosis (aOR, 2.02) regarding the development of undifferentiated NPC. The proportion of NPC cases attributable to the GG CCND1 genotype was 14.76%. Conclusions. Our results may be important in the definition of a biologic predictive profile for the development of NPC within our population. © 2006 Wiley Periodicals, Inc. Head Neck, 2006