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Clinicopathologic significance of CD105 expression in squamous cell carcinoma of the hypopharynx
Author(s) -
Chien ChihYen,
Su ChihYing,
Hwang ChungFeng,
Chuang HuiChing,
Hsiao YeaChyang,
Wu ShuLing,
Huang ChaoCheng
Publication year - 2006
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20364
Subject(s) - endoglin , medicine , stage (stratigraphy) , immunohistochemistry , metastasis , angiogenesis , hypopharyngeal cancer , pathology , cancer , oncology , vascular endothelial growth factor , vegf receptors , biology , stem cell , paleontology , genetics , cd34
Abstract Background. Induction of angiogenesis is a key process in tumor growth and metastasis. We studied the CD105 (endoglin) and vascular endothelial growth factor (VEGF) in hypopharyngeal cancer to evaluate their clinicopathologic significance. Methods. Seventy‐three patients who underwent complete excision of hypopharyngeal cancer were included in this study. Clinicopathologic data were collected retrospectively. Immunohistochemical analysis was performed with antibodies of CD105 and VEGF. Positive‐stained microvessels for CD105 were counted on hot spots of tumors. The staining intensity for VEGF was also evaluated. Results. High expression of CD105 correlated significantly with positive nodal metastasis ( p < .001) and TNM stage ( p < .01). High expression of VEGF correlated significantly with advanced tumor (T) classification ( p < .01). The overall 5‐year survival rate was worse in patients with higher CD105 expression ( p < .001), advanced TNM stage ( p < .01), advanced T classification ( p < .01), and positive nodal metastasis ( p < .001). Furthermore, Cox regression analysis revealed that CD105 expression in microvessels of tumor tissue, advanced T classification, and nodal status were independent factors for survival. Conclusion. Our results suggest that expression of CD105 is a useful predictive prognostic factor in hypopharyngeal cancer. © 2005 Wiley Periodicals, Inc. Head Neck 28: 441–446, 2006