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Concomitant low‐dose cisplatin and three‐dimensional conformal radiotherapy for locally advanced squamous cell carcinoma of the head and neck: Analysis of survival and toxicity
Author(s) -
Lau Harold,
Brar Sony,
Hao Desiree,
MacKin Jack,
Yee Don,
Gluck Stefan
Publication year - 2006
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20324
Subject(s) - medicine , chemoradiotherapy , radiation therapy , mucositis , regimen , toxicity , oncology , head and neck cancer , head and neck squamous cell carcinoma , neutropenia , surgery
Abstract Background. Our center sought to implement a simple chemoradiotherapy schedule for patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) with minimal toxicity to achieve rates of overall survival comparable to other schedules. Methods. The chemoradiotherapy schedule consisted of daily radiation to 70 Gy over 7 weeks with concurrent cisplatin 20 mg/m 2 during days 1 to 4 of weeks 1 and 5. Acute and late toxicities were recorded according to the Radiation Therapy Oncology Group (RTOG) and common toxicity criteria (CTC) grading. The overall, disease‐specific, and locoregional recurrence–free survival were calculated using the STATA statistics package. Possible factors influencing these endpoints were analyzed. Results. Fifty‐seven patients were treated, and 56 patients were evaluable for follow‐up. Median follow‐up of alive patients was 16.1 months. There was an 82% complete response rate to chemoradiotherapy. The 2‐year Kaplan–Meier overall, disease‐specific, and locoregional recurrence–free survival rates were 62%, 67%, and 63%. Acute grade 3 and 4 radiation toxicity was noted in 61% and 2%, respectively. Grade 3 or 4 hematologic toxicity was noted in 7% of patients. Factors influencing overall survival included: Karnofsky performance status, receiving more than 50% of planned chemotherapy, age, and initial hemoglobin level. Conclusion. This regimen is tolerable and achieves overall survival and locoregional control rates comparable to other chemoradiotherapy schedules. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005