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Effect of immunocompromise on metastatic cutaneous squamous cell carcinoma in the parotid and neck
Author(s) -
Southwell Katherine E.,
Chaplin John M.,
Eisenberg Robert L.,
McIvor Nicholas P.,
Morton Randall P.
Publication year - 2006
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20321
Subject(s) - medicine , neck dissection , parotidectomy , facial nerve , radiation therapy , surgery , retrospective cohort study , basal cell , carcinoma , oncology
Background. Our aim was to examine the effect of a compromised immune state on the outcomes in patients treated for metastatic cutaneous squamous cell carcinoma (SCC). Methods. A retrospective analysis of patients with metastatic cutaneous SCC to the parotid and neck treated at Greenlane Hospital between 1992 and 2002 was conducted. Outcomes were compared between immune‐competent and immunocompromised patients. A logistic regression analysis of likely risk factors for poor outcome was done. Results. Forty‐nine patients were identified, nine of whom were immunocompromised. All patients were treated by parotidectomy and/or neck dissection. The facial nerve was sacrificed in 42% of the patients. Thirty‐seven patients underwent postoperative radiotherapy (76%). Recurrence was significantly more common in the immunocompromised group (56% vs 28%), with higher rates of local and distant recurrence. Survival at 1 and 2 years was reduced. Conclusion. Immunocompromise has a significant impact on the outcome of metastatic cutaneous SCC to the parotid and neck, affecting recurrence and survival. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005