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Primary lymphoepithelioma‐like carcinoma of minor salivary gland: A case report with immunohistochemical and in situ hybridization studies
Author(s) -
Lu ShengYun,
Huang ChaoCheng,
Hsiung ChingYeh,
Eng HockLiew,
Huang HsuanYing
Publication year - 2006
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20312
Subject(s) - lymphoepithelioma like carcinoma , salivary gland , lymphoepithelioma , pathology , parotid gland , immunohistochemistry , stroma , radiation therapy , medicine , nasopharyngeal carcinoma , epstein–barr virus , virus , immunology
Abstract Background. Lymphoepithelioma‐like carcinomas (LEC) of salivary glands represent rare epithelial malignancies, with most cases affecting the parotid gland. To our knowledge, there was only one LEC arising from the minor salivary gland described in the English‐language literature. Methods. We report the second LEC of the minor salivary gland in the buccal area of a 50‐year‐old Taiwanese woman, who underwent surgical resection and adjuvant radiotherapy and remained alive and well after 120 months of follow‐up. Histologically, irregular tumor nests of undifferentiated epithelial cells with syncytial cell boundaries were found embedded within rich lymphoplasmacytic stroma. The tumor cells also showed strong c‐KIT expression and evidence of Epstein‐Barr virus (EBV) infection. Conclusions. Our case suggests potential pathogenic implications of both c‐KIT and EBV in LEC of the minor salivary gland that can be cured by the combination of surgery and radiotherapy and has a very favorable long‐term prognosis. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005