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Factors influencing long‐term survival following salvage total laryngectomy after initial radiotherapy or conservative surgery
Author(s) -
Fowler B. Zach,
Muller Susan,
Chen Amy Y.,
Johnstone Peter A. S.
Publication year - 2006
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20297
Subject(s) - medicine , laryngectomy , surgery , larynx , radiation therapy , head and neck , retrospective cohort study , overall survival , salvage therapy , salvage surgery , chemotherapy
Abstract Background. This retrospective study investigated survival outcomes of salvage total laryngectomy (STL) after initial radiation therapy (RT) or larynx conservation surgery (CS) at an academic center. Methods. A chart review yielded 64 patients with STL: 53 with RT failures, six with CS failures, and five after RT + CS. Median potential follow‐up after STL was 9.4 years (mean, 9.2 years; range, 0.3–17.4 years). Results. Five‐ and 10‐year actuarial overall survival (OS) after STL was 65.2% and 37.7%, respectively. Mean survival after STL was 7.2 years (median, 6.8 years; range, 0.2–17.4 years). No significant survival difference was found between the three treatment groups ( p = .50). For 21 patients with nodes assessed at STL, 9‐year OS was 45.4% for patients with N0 disease versus 26.7% for patients with N+ disease ( p = .25). Conclusion. These data suggest that STL after radiation failure is associated with equivalent long‐term survival as STL after RT + CS or after failure of CS alone. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005