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Advanced squamous cell carcinoma of lower gingivobuccal complex: Patterns of spread and failure
Author(s) -
Pathak Kumar Alok,
Gupta Samir,
Talole Sanjay,
Khanna Vishal,
Chaturvedi Pankaj,
Deshpande Mandar S.,
Pai Prathamesh S.,
Chaukar Devendra A.,
D'Cruz Anil K.
Publication year - 2005
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20195
Subject(s) - medicine , basal cell , multivariate analysis , retrospective cohort study , surgery , proportional hazards model , disease , survival analysis , oncology
Background. Carcinoma of the gingivobuccal complex is commonly associated with the use of smokeless tobacco known as “quid.” Methods. We conducted a retrospective chart review of 511 patients with advanced cancer of gingivobuccal complex surgically treated during 1994 to 1995. We evaluated patterns of disease failure in these patients and correlated disease‐free survival with various prognostic factors. Results. During a median follow‐up of 46 months, 159 locoregional recurrences and 11 distant metastases were detected in 148 patients. Seventy‐nine percent of the recurrences appeared within 18 months of surgery, and the median survival for patients with recurrent disease was less than 4 months. Two‐year and 5‐year disease‐free survival rates were 64% and 57%, respectively. On multivariate analysis, disease‐free survival showed significant correlation with skin involvement and extracapsular spread. Conclusions. Gingivobuccal cancers usually fail locoregionally. Soft tissue infiltration and extracapsular spread of nodal disease influence disease‐free survival. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005