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Sinonasal neuroendocrine carcinoma in association with SIADH
Author(s) -
Vasan Nilesh R.,
Medina Jesus E.,
Canfield Vikki A.,
Gillies Elizabeth M.
Publication year - 2004
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.10345
Subject(s) - medicine , malignancy , esthesioneuroblastoma , neuroendocrine carcinoma , nasal cavity , carcinoma , cancer , radiation therapy , pathology , oncology , surgery
Background. Neuroendocrine carcinoma (NEC) is a rare malignancy of the nasal cavity or paranasal sinuses. The syndrome of inappropriate ADH secretion (SIADH) has not been previously reported in association with this cancer. Methods. We report a 30‐year‐old woman with histologically confirmed neuroendocrine carcinoma who also demonstrated SIADH. After successful chemotherapy and radiotherapy treatment for the neoplasm, her SIADH resolved. A literature search found eight cases of olfactory neuroblastoma (ONB) associated with SIADH, four of which resolved after treatment of the malignancy. Results . Treatment of the underlying malignancy resulted in the immediate resolution of the SIADH. Conclusions. We report the first case of SIADH associated with NEC, which resolved after treatment of the cancer. A direct cause and effect between ONB/nasal NEC and SIADH has been established in previous reports. © 2004 Wiley Periodicals, Inc. Head Neck 26: 89–93, 2004