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Polymorphisms of GSTT1 and related genes in head and neck cancer risk
Author(s) -
Evans Adam J.,
Henner William David,
Eilers Kristi M.,
Montalto Michelle A.,
Wersinger Emily M.,
Andersen Peter E.,
Cohen James I.,
Everts Edwin C.,
McWilliams Jeffrey E.,
Beer Tomasz M.
Publication year - 2004
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.10342
Subject(s) - head and neck cancer , head and neck , genetics , gene , medicine , biology , oncology , cancer , surgery
Background . Glutathione S‐transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC). Method . Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with HNSCC and 208 population‐based controls. Results . The OR for presence of GSTT1 was 1.6 (CI, 1.1–2.5, p = 0.03). HNSCC risk was not associated with GSTM1 null genotype, the presence of the GSTP1 Val/Val genotype, or the Val/Val homozygous genotype for CYP1A1. Stratified analysis revealed disparate ORs for women (OR, 3.0; CI, 1.5–6.3) and men (OR, 1.2; CI, 0.7–2.1) for the presence of GSTT1. Conclusions . In this population, the presence of GSTT1 gene was associated with a significant increase in the risk of HNSCC. This association was particularly robust in women. © 2004 Wiley Periodicals, Inc. Head Neck 26: 63–70, 2004