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Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: Comparison with clinical and radiologic examinations
Author(s) -
Liu Ming,
Lawson Georges,
Delos Monique,
Jamart Jacques,
Ide Christophe,
Coche Emmanuel,
Weynand Birgit,
Desuter Gauthier,
Hamoir Marc,
Remacle Marc,
Marbaix Etienne
Publication year - 2003
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.10218
Subject(s) - neck dissection , medicine , metastasis , proliferating cell nuclear antigen , biopsy , palpation , pathology , head and neck cancer , head and neck squamous cell carcinoma , cancer , carcinoma , lymph node , radiology , immunohistochemistry
Background. Neck metastasis is a major prognostic factor of head and neck carcinoma, but its preoperative detection is currently unreliable. Molecular markers of the metastatic potential of a carcinoma would help to avoid unnecessary neck dissection in patients with nonmetastatic cancer. Methods. The fractions of cancer cells immunostained for proliferating cell nuclear antigen (PCNA) and Ki67 were determined in 80 preoperative biopsy specimens of head and neck carcinomas. The value of both indexes to detect metastasis in the subsequent neck dissection was compared with that of the clinical and radiologic examinations. Results. PCNA and Ki67 indexes correlated with neck metastasis. Cutoff points were determined for both indexes to discriminate metastatic from nonmetastatic carcinomas. By multivariate logistic regression, these indexes were significant predictors of metastases, together with clinical T stage and neck palpation. Conclusion. The fraction of cancer cells immunolabeled for PCNA or Ki67 in preoperative biopsy specimens is helpful to predict neck metastasis. © 2003 Wiley Periodicals, Inc. Head Neck 25: 280–288, 2003