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Soluble Tie‐2 receptor levels independently predict locoregional recurrence in head and neck squamous cell carcinoma
Author(s) -
Homer Jarrod J.,
Greenman John,
Drevs Joachim,
Marme Dieter,
Stafford Nicholas D.
Publication year - 2002
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.10123
Subject(s) - head and neck squamous cell carcinoma , medicine , oncology , head and neck , head and neck cancer , basal cell , receptor , carcinoma , cancer , surgery
Background This study assessed two circulating angiogenic receptors as tumor markers in patients with head and neck squamous cell carcinoma (HNSCC): soluble vascular endothelial factor growth receptor‐1 (sVEGFR1) and soluble Tie‐2 receptor (sTie2R). Methods Sera from 79 newly presenting patients with HNSCC and from 22 controls were assayed using sandwich ELISA. Median follow‐up was 35 months after curative treatment. Analysis was carried out to compare levels between HNSCC patients and controls and to ascertain relationships with clinicopathologic and outcome variables. Results Soluble VEGFR1 was not elevated in the HNSCC group and was not related to any of the clinicopathologic or outcome variables. Soluble Tie2R was also not elevated in HNSCC patients or related to the clinicopathologic variables but was associated with locoregional recurrence ( p = .009). Raised sTie2R (>64 ng/mL) independently predicted recurrence ( p = .007) with a relative risk of 3.0 (95% CI, 1.7–5.0). Conclusions Soluble Tie2R is an independent predictor of locoregional recurrence in HNSCC. © 2002 Wiley Periodicals, Inc. Head Neck 24: 773–778, 2002