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Novel approach to the design of potential bioactive alkaloid anabasine conjugates using click chemistry methodology
Author(s) -
Artyushin Oleg I.,
Vinogradova Natalya M.,
Sharova Elena V.,
Genkina Galina K.,
Brel Valery K.
Publication year - 2016
Publication title -
heteroatom chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.283
H-Index - 42
eISSN - 1098-1071
pISSN - 1042-7163
DOI - 10.1002/hc.21322
Subject(s) - anabasine , chemistry , cycloaddition , click chemistry , conjugate , alkaloid , combinatorial chemistry , acetylcholine receptor , organic chemistry , receptor , catalysis , biochemistry , mathematical analysis , mathematics
Anabasine‐containing azides and acetylenes were used as building blocks in copper(I)‐catalyzed 1,3‐dipolar cycloaddition reactions with a series of acetylenes and azides via click methodology to provide a range of anabasine conjugates being potential ligands for neuronal nicotinic acetylcholine receptors.

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