Novel approach to the design of potential bioactive alkaloid anabasine conjugates using click chemistry methodology | Zendy

Artyushin Oleg I. | Zendy; Vinogradova Natalya M. | Zendy; Sharova Elena V. | Zendy; Genkina Galina K. | Zendy; Brel Valery K. | Zendy

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Novel approach to the design of potential bioactive alkaloid anabasine conjugates using click chemistry methodology

Author(s) -

Artyushin Oleg I.,

Vinogradova Natalya M.,

Sharova Elena V.,

Genkina Galina K.,

Brel Valery K.

Publication year - 2016

Publication title -

heteroatom chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.283

H-Index - 42

eISSN - 1098-1071

pISSN - 1042-7163

DOI - 10.1002/hc.21322

Subject(s) - anabasine , chemistry , cycloaddition , click chemistry , conjugate , alkaloid , combinatorial chemistry , acetylcholine receptor , organic chemistry , receptor , catalysis , biochemistry , mathematical analysis , mathematics

Anabasine‐containing azides and acetylenes were used as building blocks in copper(I)‐catalyzed 1,3‐dipolar cycloaddition reactions with a series of acetylenes and azides via click methodology to provide a range of anabasine conjugates being potential ligands for neuronal nicotinic acetylcholine receptors.

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