Open AccessPalladium N ‐heterocyclic‐carbene‐catalyzed ortho‐arylation of benzaldehyde derivatives
Author(s) -
Dogan Öznur,
Gürbüz Nevin,
Özdemir İsmail,
Çetinkaya Bekir
Publication year - 2008
Publication title -
heteroatom chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.283
H-Index - 42
eISSN - 1098-1071
pISSN - 1042-7163
DOI - 10.1002/hc.20479
Subject(s) - chemistry , carbene , heteroatom , benzaldehyde , catalysis , palladium , steric effects , medicinal chemistry , aryl , organic chemistry , ring (chemistry) , alkyl
New, sterically demanding 1,3‐dialkylbenzimidazolium salts ( 2a–c ) as N ‐heterocyclic‐carbene precursors have been synthesized and characterized. The ortho position of aromatic aldehydes was directly and selectively arylated with aryl chlorides in the presence of a catalytic system prepared in situ from Pd(OAc) 2 , 1,3‐dialkylbenzimidazolium chlorides ( 2a–c ), and Cs 2 CO 3 . © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:569–574, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20479