Open AccessA convenient one‐pot synthesis of 1,2‐azaphospholanium salts
Author(s) -
Aladzheva Inga M.,
Lobanov Dmitrii I.,
Bykhovskaya Ol'ga V.,
Petrovskii Pavel V.,
Lyssenko Konstantin A.,
Mastryukova Tatyana A.
Publication year - 2003
Publication title -
heteroatom chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.283
H-Index - 42
eISSN - 1098-1071
pISSN - 1042-7163
DOI - 10.1002/hc.10209
Subject(s) - chemistry , heteroatom , intramolecular force , alkylation , hydrolysis , phosphorus , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , ring (chemistry)
A novel facile one‐pot synthesis of the 1,2‐azaphospholanes by intramolecular alkylation of 3‐halopropyl amides of tricoordinate phosphorus has been suggested. Using this method, a series of the differently N‐substituted 1,2‐azaphospholanium salts were synthesized. 3‐Aminopropylphosphine oxides were obtained by hydrolysis of the salts. A probable mechanism of the 1,2‐azaphospholanium salts formation is discussed. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:596–602, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10209