N ‐[4‐(dicyanomethylazo)phenyl]‐2‐saccharin‐2‐ylacetamide in the synthesis of pyridazine and pyrimidine derivatives | Zendy

Aly A. A. | Zendy; Nassar S. A. | Zendy

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N ‐[4‐(dicyanomethylazo)phenyl]‐2‐saccharin‐2‐ylacetamide in the synthesis of pyridazine and pyrimidine derivatives

Author(s) -

Aly A. A.,

Nassar S. A.

Publication year - 2004

Publication title -

heteroatom chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.283

H-Index - 42

eISSN - 1098-1071

pISSN - 1042-7163

DOI - 10.1002/hc.10194

Subject(s) - chemistry , pyridazine , pyrimidine , heteroatom , acetamide , saccharin , reagent , organic chemistry , medicinal chemistry , stereochemistry , ring (chemistry) , medicine , endocrinology

N ‐[4‐(Dicyanomethylazo)phenyl]‐2‐saccharin‐2‐ylacetamide ( 2 ) proved to be a convenient precursor for the synthesis of a variety of pyridazine and pyrimidine derivatives 4a,b,6 , and 7 . Also a series of substituted pyrimidines 10–16 were prepared from the reaction of N ‐[4‐(2‐amino‐1‐cyano‐2‐substitutedvinylazo)phenyl]‐2‐(saccharin‐2‐yl)acetamide 9a,b with different reagents via initial addition to either the cyano or amino group, followed by cyclization. Some of the synthesized heterocycles were screened for their biological activity. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 15:2–8, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10194

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