Open AccessN ‐[4‐(dicyanomethylazo)phenyl]‐2‐saccharin‐2‐ylacetamide in the synthesis of pyridazine and pyrimidine derivatives
Author(s) -
Aly A. A.,
Nassar S. A.
Publication year - 2004
Publication title -
heteroatom chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.283
H-Index - 42
eISSN - 1098-1071
pISSN - 1042-7163
DOI - 10.1002/hc.10194
Subject(s) - chemistry , pyridazine , pyrimidine , heteroatom , acetamide , saccharin , reagent , organic chemistry , medicinal chemistry , stereochemistry , ring (chemistry) , medicine , endocrinology
N ‐[4‐(Dicyanomethylazo)phenyl]‐2‐saccharin‐2‐ylacetamide ( 2 ) proved to be a convenient precursor for the synthesis of a variety of pyridazine and pyrimidine derivatives 4a,b,6 , and 7 . Also a series of substituted pyrimidines 10–16 were prepared from the reaction of N ‐[4‐(2‐amino‐1‐cyano‐2‐substitutedvinylazo)phenyl]‐2‐(saccharin‐2‐yl)acetamide 9a,b with different reagents via initial addition to either the cyano or amino group, followed by cyclization. Some of the synthesized heterocycles were screened for their biological activity. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 15:2–8, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10194