Open AccessCortical surface modeling reveals gross morphometric correlates of individual differences
Author(s) -
Loftus William C.,
Tramo Mark Jude,
Gazzaniga Michael S.
Publication year - 1995
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.460030402
Subject(s) - neuroscience , magnetic resonance imaging , biology , anatomy , lateralization of brain function , brain morphometry , psychology , medicine , radiology
Advances in human neurobiology are now made possible through methods which combine structural magnetic resonance imaging (MRI), three‐dimensional reconstruction, and statistical analysis. MRI‐based reconstruction enables the in vivo quantification of regional cortical surface area (rCSA) while inter‐group comparisons uncover relationships of cortical morphometry with genotype, sex, and developmental abnormalities. In studies on normals we have found strong associations between the rCSA of monozygotic twins as compared to unrelated pairings. Further analysis of this data uncovered significant differences between the male and female twins in left hemisphere rCSA. When these methods were applied to brains of dyslexic subjects and controls, we identified a pattern of differences involving all major subdivisions of both hemispheres. Taken together, these techniques can illuminate structurefunction issues in both normal and diseased brains. ©1996 Wiley‐Liss, Inc.