Open AccessOne‐week escitalopram intake alters the excitation–inhibition balance in the healthy female brain
Author(s) -
Zsido Rachel G.,
Molloy Eóin N.,
Cesnaite Elena,
Zheleva Gergana,
Beinhölzl Nathalie,
Scharrer Ulrike,
Piecha Fabian A.,
Regenthal Ralf,
Villringer Arno,
Nikulin Vadim V.,
Sacher Julia
Publication year - 2022
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.25760
Subject(s) - escitalopram , excitatory postsynaptic potential , placebo , citalopram , psychology , resting state fmri , medicine , anesthesia , neuroscience , inhibitory postsynaptic potential , antidepressant , pathology , hippocampus , alternative medicine
Neural health relies on cortical excitation–inhibition balance (EIB). Previous research suggests a link between increased cortical excitation and neuroplasticity induced by selective serotonin reuptake inhibitors (SSRIs). Whether there are modulations of EIB following SSRI‐administration in the healthy human brain, however, remains unclear. Thus, in a randomized double‐blind study, we administered a clinically relevant dose of 20 mg escitalopram for 7 days (time when steady state is achieved) in 59 healthy women (28 escitalopram, 31 placebo) on oral contraceptives. We acquired resting‐state electroencephalography data at baseline, after a single dose, and at steady state. We assessed 1/ f slope of the power spectrum as a marker of EIB, compared individual trajectories of 1/ f slope changes contrasting single dose and 1‐week drug intake, and tested the relationship of escitalopram plasma levels and cortical excitatory and inhibitory balance shifts. Escitalopram‐intake was associated with decreased 1/ f slope, indicating an EIB shift in favor of excitation. Furthermore, 1/ f slope at baseline and after a single dose of escitalopram was associated with 1/ f slope at steady state. Higher plasma escitalopram levels at a single dose were associated with better maintenance of these EIB changes throughout the drug administration week. These findings demonstrate the potential for 1/ f slope to predict individual cortical responsivity to SSRIs and widen the lens through which we map the human brain by testing an interventional psychopharmacological design in a clearly defined endocrinological state.