Open AccessLocal shape volume alterations in subcortical structures of suicide attempters with major depressive disorder
Author(s) -
Kang Wooyoung,
Shin JeongHyeon,
Han KyuMan,
Kim Aram,
Kang Youbin,
Kang June,
Tae WooSuk,
Paik JongWoo,
Lee HaeWoo,
Seong JoonKyung,
Ham ByungJoo
Publication year - 2020
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.25168
Subject(s) - suicidal ideation , basal ganglia , psychology , putamen , thalamus , depression (economics) , major depressive disorder , amygdala , suicide attempt , neuroscience , psychiatry , clinical psychology , poison control , medicine , injury prevention , central nervous system , environmental health , economics , macroeconomics
Suicide is among the most important global health concerns; accordingly, an increasing number of studies have shown the risks for suicide attempt(s) in terms of brain morphometric features and their clinical correlates. However, brain studies addressing suicidal vulnerability have been more focused on demonstrating impairments in cortical structures than in the subcortical structures. Using local shape volumes (LSV) analysis, we investigated subcortical structures with their clinical correlates in depressed patients who attempted suicide. Then we compared them with depressed patients without a suicidal history and age‐ and sex‐matched healthy controls (HCs; i.e., 47 suicide attempters with depression, 47 non‐suicide attempters with depression, and 109 HCs). Significant volumetric differences were found between suicidal and nonsuicidal depressed patients in several vertices: 16 in the left amygdala; 201 in the left hippocampus; 1,057 in the left putamen; and 140 in the left pallidum; 1 in the right pallidum; and 6 in the bilateral thalamus. These findings indicated subcortical alterations in LSV in components of the limbic–cortical–striatal–pallidal–thalamic circuits. Moreover, our results demonstrated that the basal ganglia was correlated with perceived stress levels, and the thalamus was correlated with suicidal ideation. We suggest that suicidality in major depressive disorder may involve subcortical volume alterations.