Open AccessMega‐analysis methods in ENIGMA : The experience of the generalized anxiety disorder working group
Author(s) -
Zugman André,
Harrewijn Anita,
Cardinale Elise M.,
Zwiebel Hannah,
Freitag Gabrielle F.,
Werwath Katy E.,
BasHoogendam Janna M.,
Groenewold Nynke A.,
Aghajani Moji,
Hilbert Kevin,
Cardoner Narcis,
PortaCasteràs Daniel,
Gosnell Savannah,
Salas Ramiro,
Blair Karina S.,
Blair James R.,
Hammoud Mira Z.,
Milad Mohammed,
Burkhouse Katie,
Phan K. Luan,
Schroeder Heidi K.,
Strawn Jeffrey R.,
BeesdoBaum Katja,
Thomopoulos Sophia I.,
Grabe Hans J.,
Van der Auwera Sandra,
Wittfeld Katharina,
Nielsen Jared A.,
Buckner Randy,
Smoller Jordan W.,
Mwangi Benson,
Soares Jair C.,
Wu MonJu,
ZuntaSoares Giovana B.,
Jackowski Andrea P.,
Pan Pedro M.,
Salum Giovanni A.,
Assaf Michal,
Diefenbach Gretchen J.,
Brambilla Paolo,
Maggioni Eleonora,
Hofmann David,
Straube Thomas,
Andreescu Carmen,
Berta Rachel,
Tamburo Erica,
Price Rebecca,
Manfro Gisele G.,
Critchley Hugo D.,
Makovac Elena,
Mancini Matteo,
Meeten Frances,
Ottaviani Cristina,
Agosta Federica,
Canu Elisa,
Cividini Camilla,
Filippi Massimo,
Kostić Milutin,
Munjiza Ana,
Filippi Courtney A.,
Leibenluft Ellen,
Alberton Bianca A. V.,
Balderston Nicholas L.,
Ernst Monique,
Grillon Christian,
MujicaParodi Lilianne R.,
Nieuwenhuizen Helena,
Fonzo Gregory A.,
Paulus Martin P.,
Stein Murray B.,
Gur Raquel E.,
Gur Ruben C.,
Kaczkurkin Antonia N.,
Larsen Bart,
Satterthwaite Theodore D.,
Harper Jennifer,
Myers Michael,
Perino Michael T.,
Yu Qiongru,
Sylvester Chad M.,
Veltman Dick J.,
Lueken Ulrike,
Van der Wee Nic J. A.,
Stein Dan J.,
Jahanshad Neda,
Thompson Paul M.,
Pine Daniel S.,
Winkler Anderson M.
Publication year - 2022
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.25096
Subject(s) - anxiety , generalized anxiety disorder , psychology , neuroimaging , group (periodic table) , group analysis , quality (philosophy) , data science , cognitive psychology , computer science , neuroscience , social psychology , psychiatry , philosophy , chemistry , organic chemistry , epistemology
The ENIGMA group on Generalized Anxiety Disorder (ENIGMA‐Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega‐analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between‐country transfer of subject‐level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega‐analyses.