Open AccessENIGMA brain injury: Framework, challenges, and opportunities
Author(s) -
Dennis Emily L.,
Baron David,
BartnikOlson Brenda,
Caeyenberghs Karen,
Esopenko Carrie,
Hillary Frank G.,
Kenney Kimbra,
Koerte Inga K.,
Lin Alexander P.,
Mayer Andrew R.,
Mondello Stefania,
Olsen Alexander,
Thompson Paul M.,
Tate David F.,
Wilde Elisabeth A.
Publication year - 2022
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.25046
Subject(s) - traumatic brain injury , neuroimaging , injury prevention , medicine , poison control , psychology , socioeconomic status , neuroscience , physical medicine and rehabilitation , psychiatry , medical emergency , environmental health , population
Traumatic brain injury (TBI) is a major cause of disability worldwide, but the heterogeneous nature of TBI with respect to injury severity and health comorbidities make patient outcome difficult to predict. Injury severity accounts for only some of this variance, and a wide range of preinjury, injury‐related, and postinjury factors may influence outcome, such as sex, socioeconomic status, injury mechanism, and social support. Neuroimaging research in this area has generally been limited by insufficient sample sizes. Additionally, development of reliable biomarkers of mild TBI or repeated subconcussive impacts has been slow, likely due, in part, to subtle effects of injury and the aforementioned variability. The ENIGMA Consortium has established a framework for global collaboration that has resulted in the largest‐ever neuroimaging studies of multiple psychiatric and neurological disorders. Here we describe the organization, recent progress, and future goals of the Brain Injury working group.