Open AccessCover Image
Author(s) -
Kashyap Rajan,
Bhattacharjee Sagarika,
Yeo B. T. Thomas,
Chen S. H. Annabel
Publication year - 2020
Publication title -
human brain mapping
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.24649
Subject(s) - functional magnetic resonance imaging , neuroimaging , posterior cingulate , resting state fmri , psychology , clinical psychology , neuroscience
COVER ILLUSTRATION Resting‐state functional magnetic resonance imaging (rs‐fMRI) is widely used to compare relevant features of the resting‐state brain between a clinically‐disordered and healthy‐control group. Thus, the rsfMRI of individuals in a healthy‐control group that constitutes the baseline of comparison plays a vital role in the appropriate understanding of the differences between the underlying neural processes. However, individuals recruited for the healthy‐control group have different personalities and lifestyle habits, an autograph of which is carried in their brain activity but underestimated in neuroimaging based comparison studies. With this objective, subtype within the healthy‐control group was identified from the rs‐fMRI. The subtype reflected reduced weights in the posterior cingulate regions. The individuals in the subtype had higher usage of marijuana, illicit drugs, alcohol, and tobacco; and had a predisposition towards antisocial personality problems. Thus, heterogeneity within healthy individuals indicates extension of the boundaries for appropriate selection of subjects in the control group.