Open AccessWhite matter tracts lesions and decline of verbal fluency after deep brain stimulation in Parkinson's disease
Author(s) -
Costentin Guillaume,
Derrey Stéphane,
Gérardin Emmanuel,
Cruypeninck Yohann,
PressatLaffouilhere Thibaut,
Anouar Youssef,
Wallon David,
Le Goff Floriane,
Welter MarieLaure,
Maltête David
Publication year - 2019
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.24544
Subject(s) - deep brain stimulation , white matter , arcuate fasciculus , inferior longitudinal fasciculus , optic tract , subthalamic nucleus , superior longitudinal fasciculus , psychology , fasciculus , disconnection , neuroscience , verbal fluency test , parkinson's disease , pyramidal tracts , anatomy , medicine , magnetic resonance imaging , neuropsychology , pathology , tractography , radiology , disease , optic nerve , cognition , political science , law , fractional anisotropy
Decline of verbal fluency (VF) performance is one of the most systematically reported neuropsychological adverse effects after subthalamic nucleus deep brain stimulation (STN‐DBS). It has been suggested that this worsening of VF may be related to a microlesion due to the electrode trajectories. We describe the disruption of surrounding white matter tracts following electrode implantation in Parkinson's disease (PD) patients with STN‐DBS and assess whether damage of fiber pathways is associated with VF impairment after surgery. We retrospectively analyzed 48 PD patients undergoing bilateral STN DBS. The lesion mask along the electrode trajectory transformed into the MNI 152 coordinate system, was compared with white matter tract atlas in Tractotron software, which provides a probability and proportion of fibers disconnection. Combining tract‐ and atlas‐based analysis reveals that the trajectory of the electrodes intersected successively with the frontal aslant tract, anterior segment of arcuate tract, the long segment of arcuate tract, the inferior longitudinal fasciculus, the superior longitudinal fasciculus, the anterior thalamic radiation, and the fronto striatal tract. We found no association between the proportion fiber disconnection and the severity of VF impairment 6 months after surgery. Our findings demonstrated that microstructural injury associated with electrode trajectories involved white matter bundles implicated in VF networks.